Danny Glover ... Simon
Kevin Kline ... Mack
Steve Martin ... Davis
Mary McDonnell ... Claire
Mary-Louise Parker ... Dee
Alfre Woodard ... Jane
Jeremy Sisto ... Roberto
Tina Lifford ... Deborah
Patrick Malone ... Otis
Randle Mell ... The Alley Baron
Sarah Trigger ... Vanessa
Destinee DeWalt ... Kelley
Candace Mead ... Claire's Baby
Lauren Mead ... Claire's Baby (as Loren Mead)
Shaun Baker ... Rocstar
K. Todd Freeman ... Wipe
Deon Sams ... Jimmy
Christopher M. Brown ... Rotor
Gregg Dandridge ... Eddie
Branscombe Richmond ... Ace Cop
Walt Jordan ... Deuce Cop
Todd Allen ... Myers
Carole White ... Morning Nurse (as Carole Ita White)
Basil Wallace ... Insurance Salesman
Georgina Lindsey ... Cathy Fox
Jack Kehler ... Steve Fox
Marley Shelton ... Amanda (as Marlee Shelton)
Lynn Salvatori ... Woman in Baseball Cap
Jim Morange ... Bus Driver
Henry Kingi ... Skin
Steven Keith Davis ... Scar
Sharon Lee Jones ... Studio Girl
Mary Ellen Trainor ... Ms. Green
Ben Chaney ... Young Roberto
Gary Carlos Cervantes ... Watch Robber (as Gary Cervantes)
Ben McCreary ... Jackson
Jeanne Bates ... Mrs. Menken
Sam H. Ginsburg ... Mr. Menken
Brett A. Jones ... Window-Breaking Thug
Paul E. Short ... Myers' Partner (as Paul Short)
Willie C. Carpenter ... Simon's Friend
Antonio Royuela ... Carlos
Edward G. Perez ... Carlos' Friend #1 (as Eddie Perez)
Clifton Collins Jr. ... Carlos' Friend #2 (as Clifton Gonzalez Gonzalez)
Hugh Ross ... Davis' Assistant (as Hugh R. Ross)
Anne Ward ... Davis' Assistant
Roxanne Kasdan ... Davis' Assistant
Cora Lee Day ... Woman in Car
John Ashby ... Woman's Driver
Jacqueline Alexandra Citron ... Forum Twin #1 (as Jacqueline Alexandra)
Kristen Amber Citron ... Forum Twin #2 (as Kristen Amber)
Jorga Caye ... Sports Event (uncredited)
Lawrence Kasdan ... Director in Screening Room (uncredited)
Damon Stout ... Baseball Player (uncredited)
Dennis Wyatt ... Basketball Player (uncredited)