Danny DeVito ... Frank Menure
Kathy Bates ... Agnes Menure
Ron Livingston ... Dr. Richard Clayton
Neve Campbell ... Ellen Minnola
Beverly D'Angelo ... Angela Minnola
Bob Odenkirk ... Mitch Clayton
Edward Herrmann ... Doug Clayton
Christine Baranski ... Arleen Clayton
Martin Mull ... Jeffry Morton
Michael McKean ... Ken Hymanv M.C. Gainey ... Spicer
Star Jones ... Holly Davis
Ed Begley Jr. ... Mr. Manoire
Debbi Morgan ... Mrs. Manoire
Pete Schwaba ... Meat Delivery Man
Jimmy Pardo ... Angry Driver
Dierdre Holder ... Carol
Rose Abdoo ... Frustrated Housewife
Terry Cooley ... Prison Inmate
Connie Sawyer ... Old Lady
William Dennis Hurley ... Angry Bookstore Guy
Tracey Walter ... Toupee Salesman
Jeffrey James Shoe ... Carnival Guy (as Jeff Shoe)
Christa Campbell ... Carnival Girl
Sam Rubin ... TV Anchorman
Anna Davidson ... Opera Singer
Mary Ruth Clarke ... Cafe Passerby
Robert Harvey ... Tailor (as Bob Harvey)
Joe Goddard ... Pastor