Keanu Reeves ... Nelson Moss
Charlize Theron ... Sara Deever
Jason Isaacs ... Chaz Watley
Greg Germann ... Vince Holland
Liam Aiken ... Abner
Robert Joy ... Raeford Dunne
Lauren Graham ... Angelica
Michael Rosenbaum ... Brandon / Brandy
Frank Langella ... Edgar Price
Jason Kravits ... Manny
Ray Baker ... Buddy Leach
Tom Bullock ... Al
Adele Proom ... Osiris
L. Peter Callender ... Don Watson, DMV Proctor
June Carryl ... Beatrice (as June Lomena)
Kelvin Han Yee ... Burly Man
David Fine ... Homeless Man
Elizabeth Weber ... Lexy
Doreen Foo Croft ... Chinese Woman (as Doreen Croft)
Susan Zelinsky ... Waitress
Kathy Garver ... Nurse
Charles Isen ... Bald Man (as Chuck Isen)
Igor Hiller ... Kid #1
Chase Oliver ... Kid #2
Nathan McAlone ... Kid #3
Garth Kravits ... Techie Nerd with Sub
Karina Andrews ... Office Manager
Sanford Marshall ... Clown on Train
Tessa Koning-Martinez ... Marie
Diane Amos ... Rachel, Coffee Shop Waitress
Jeffrey Patrick Dean ... Art Dept. Coordinator #1
Diana C. Weng ... Art Dept. Coordinator #2
Milo Young ... Art Dept. Coordinator #3
Meghan Marx ... Art Dept. Coordinator #4
Rueben Grundy ... Art Dept. Coordinator #5
Raquel Aurilia ... Cute Cashier
Kaliopi Eleni ... Woman on Train
Eric Kouba ... Big Brother Organizer
Kathy McGraw ... Billy Boy's Mother
Tyler Bell ... Billy Boy
Ann W. Leon ... Hospital Administrator
Lisa Marie Tudor ... Nurse Nancy
John Lewis ... Jack the Barman
Andy Arness ... Club Patron (uncredited)
Joe Bellan ... Cabbie (uncredited)
Wahayn Inello Clayton ... San Francisco Pedestian (uncredited)
Jesse Jensen ... YMCA Counselor (uncredited)
Peter Kepler ... Train Passenger (uncredited)
Brian Leonard ... Radio Announcer (uncredited)
Annie Lore ... DMV Customer (uncredited)
Theodore Carl Soderberg ... A Father (uncredited)
Johnpaul Williams ... Handsome Coffee Shop Barista (uncredited)